For example, KCa3.1 blockade with the small molecule TRAM‐34 has been shown to have beneficial effects in a rat MCAO ischemia model and to protect neurons from neurotoxicity caused by microglia activated with β‐amyloid (Aβ) oligomers (Figure 1) (Maezawa, Zimin, Wulff, & Jin, 2011). The gene discussed is KCNN4; the disease is ischemia.