The PANTHER Pathways included signaling mediated by the following: histamine H1 receptor; oxytocin receptor; phosphoinositide 3-kinase (PI3K); thyrotropin-releasing hormone receptor; Alzheimer’s disease (AD)-amyloid secretase; epidermal growth factor receptor (EGFR); 5-HT2 type receptor; and fibroblast growth factor (FGF). Here, TRHR is linked to early-onset autosomal dominant Alzheimer disease.