For instance, in mice with Pseudomonas infection and hypoxic lung damage, treatment with a neutralising anti-HMGB1 monoclonal antibody resulted in an increase in leukocyte phagocytic activity compared with mice receiving control mAb, and this improved phagocytic function was associated with reduced concentrations of airway HMGB130. The gene discussed is HMGB1; the disease is Pseudomonas infection.