Taken together, 13 transcription factors associated with ovarian cancer cisplatin-resistance and metastasis were identified, of which four were up-regulated (HOXD8(1), HOXD8(2), RB, RFX1/2/3) and nine down-regulated (SRE, FKHR, Angiotensinogen ANG-IRE, Pax2, CD28RC/NF-IL2B, HLF, CPE, CBFB and c-Ets-1) (Fig. 3C–E). This evidence concerns the gene HLF and ovarian cancer.