Preoperative cholesterol (P = 0.002), preoperative albumin (P < 0.001), Child-Pugh score (P < 0.001), early postoperative CONUTS ≥ 8 (P < 0.001), early postoperative albumin (P < 0.001), early postoperative cholesterol (P < 0.001), intraoperative blood loss (P < 0.001), transfusion (P < 0.001), major liver resection (P = 0.001), pathological indexes included tumor differentiation (P = 0.006) and cirrhosis (P = 0.039) were identified as the significant factors for postoperative complication III-V. The gene discussed is ALB; the disease is Cirrhosis.