Upregulation of Mlkl in TA of 3- and 9-week-old mdx and the presence of phospho-MLKL-positive myofibres in DMD muscles (Fig. 1k, l) further indicates necroptosis activation in human dystrophin deficiency. The gene discussed is MLKL; the disease is neuromuscular disease caused by qualitative or quantitative defects of dystrophin.