IL4R and Cognitive impairment: Our observed decrease in expression by more than 50% of several pro-inflammatory proteins with systemic infection should be considered in relation to the upregulation of the anti-inflammatory genes IL4R and CHI3L1. The role of IL4 in AD is uncertain: higher peripheral IL4 was found in mild cognitive impairment patients but not in dementia; increased disease severity was associated with lower levels of IL4 [36].