To assess the effect of systemic infection on the neuroinflammatory environment in AD, we used the MSD platform to measure the levels of IFNγ, IL1β, IL2, IL4, IL6, IL8, IL10, IL12p70, IL13, TNFα, IL1α, IL5, IL7, IL12/IL23p40, IL15, IL16, IL17A, GM-CSF, TNFβ and VEGF in AD- and AD+ groups. The gene discussed is IL1A; the disease is Alzheimer disease.