For these experiments, we used U87MG human GBM cells and exosomes, since we expected to characterize any functional effects in future experiments through stable transduction of dominant negative and constitutive mutant forms of K-Ras (005 GBM cells are already stably transduced with Flag-H-RasV12, precluding their use for these studies). The gene discussed is KRAS; the disease is glioblastoma.