To identify individuals at elevated risk for pancreatic cancer in a population of European ancestry, Klein et al. estimated the absolute risk of pancreatic cancer development with a risk model (based on three GWAS-identified SNPs, sex, age, ABO genotype, family history of pancreatic cancer, body mass index, cigarette smoking, and heavy alcohol intake) and incidence data from the SEER registries[13]. This evidence concerns the gene ABO and familial pancreatic carcinoma.