TNF and skin disorder: Blockade of the EGFR pathway increases chemokine production and leads to enhanced immune cell infiltration of the skin [37] Interestingly, in these skin disorders the activation of EGFR was the result of increased levels of soluble EGFR ligands produced by keratinocytes in response to IFNγ and TNFα present in the milieu [37], suggesting that EGFR-mediated suppression of chemokine production can occur because of constitutive EGFR-signaling but also as result of an adaptive negative feed-back loop.