Whilst others observed that EGFR inhibition can lead to the direct increased secretion of proinflammatory cytokines, including IL2, IL4, IL6, IL8, GMCSF [30], our study showed an increased expression of CCL2, CCL5, CXCL9, CXCL10 after EGFR blockade only when the tumor cells were stimulated with IFNγ and TNFα. Here, IL2 is linked to neoplasm.