Recently, some cases of gliomas have been found to be associated with somatic mutations in the gene encoding isocitrate dehydrogenases (IDH) 1/2, with point mutations at highly conserved residues in the active sites of IDH1 (e.g. R132H) and IDH2 (e.g. R172K) [2, 3]. Here, IDH2 is linked to glioma.