Although this mouse MI model has translational relevance for non-reperfused human ST-elevation myocardial infarction [43], further studies are necessary to examine the effect of ischemia and reperfusion on cardiac corin expression and blood levels given that reperfusion mediated by percutaneous coronary intervention and fibrinolysis are routine therapeutic strategies for ST-elevation myocardial infarction patients in clinical practice. This evidence concerns the gene CORIN and ischemia.