The TDO group presented reduced TNF-α/IL-10 ratio as compared to DO group and similar values when compared to E and D groups (E: 5.18±1.34; D: 11.65±3.34; DO: 20.62±3.01 and TDO: 6.72±1.38) (Fig 2). The gene discussed is TNF; the disease is tricho-dento-osseous syndrome.