USP22 and cancer: For example, misregulation of H2Bub homeostasis appears to be central in the transcriptional events linked to human oncogenesis, as USP22 transcript abundance is part of an 11-gene signature that associates with poor cancer prognosis (Jeusset and McManus, 2017), hence potentially influencing cell proliferation processes like human DET1 (Pick et al., 2007; Wertz et al., 2004).