By contrast, mice with homozygous Tp53 deletion mainly develop lymphoma, with rare cases of angiosarcoma, undifferentiated sarcoma, osteosarcoma, rhabdomyosarcoma, testicular tumors, nervous system tumors, teratoma, and mammary carcinoma being reported (Donehower et al., 1992; Harvey et al., 1993; Jacks et al., 1994). This evidence concerns the gene TP53 and angiosarcoma.