For example, the TP53 locus is mutated in 16% of human embryonal rhabdomyosarcoma (ERMS), a common pediatric cancer of muscle and transcriptional activity is altered in >30% of human ERMS through TP53 locus disruption or MDM2 amplification (Taylor et al., 2000). This evidence concerns the gene TP53 and embryonal rhabdomyosarcoma.