Such a cell line can be adapted for high-throughput chemical screens for inhibitors against sumoylation, ubiquitylation, or Cdc48, which can not only be used as research tools, but also be developed into potential therapies for Pol III-related disorders or other human diseases involving SUMO, ubiquitin, or Cdc48, such as cancer (Kessler et al., 2012). Here, VCP is linked to cancer.