IL1R1 and neoplasm: Moreover, once recruited, tumour‐associated leukocytes, in particular macrophages, may secrete additional IL‐1β further potentiating a feedback loop of chemokine release, leukocyte recruitment and inflammation within the tumour microenvironment that drives tumour progression.42 Although further studies are warranted, it is interesting to speculate that IL‐1/IL‐1R inhibitors may prevent accumulation of tumour‐associated myeloid cells, improving outcome.