Indeed, in a prospective study, the presence of elevated levels of tumour‐infiltrating CD8+ T‐cells correlated with a good prognosis in HPV‐positive compared to HPV‐negative OPC.19, 32, 45, 46 Interestingly, we found levels of CCL5 as well as other T‐cell chemokines were elevated in HPV‐negative compared to HPV‐positive OPC stromal interactions. This evidence concerns the gene CD8A and neoplasm.