The previous experiment has implied that the phase transition was regulated by G0/G1 switch gene 2 (G0S2), which might be a significant regulator of HCC cells proliferation via activating PPARα, a key regulator of fatty acid catabolism in the liver (106), therefore hsa_circ_0005986 may be involved in HCC progression through regulating cell proliferation of HCC. This evidence concerns the gene G0S2 and hepatocellular carcinoma.