CD274 and malignant colon neoplasm: In mouse models of aggressive ovarian and colon cancers, combination of OV expressing CXCL-11 (C-X-C motif of chemokine 11 precursor) with PD-L1 blockade markedly increased PD-L1 expression in TMEs, eliminated MDSC, Treg, and TAM immunosuppressive cells, and boosted T-cell infiltration, leading to complete responses in 40% of cases (148).