Upon activation of both promoters exclusively within specific cancer cells, the AND gate expressed GAD fusion proteins to drive co-expression of a suite of immunomodulators termed “SCIP” comprising: (i) surface T-cell engagers (STE) and chemokines (CCL21) to label tumors for T-cell mediated destruction; (ii) IL12 cytokines to boost T-cell activation and effector activity; and (iii) PD-1 checkpoint blockade (155). This evidence concerns the gene PDCD1 and cancer.