MYC and lymphoma: Some reviews recommend more intensive chemotherapy regimens such as EPOCH (etoposide, doxorubicin, and cyclophosphamide with vincristine and prednisone) or hyper CVAD/MA (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and cytarabine), especially given the role of MYC alterations in the pathogenesis of this lymphoma [77].