The literature indicates that the progressive plaques in the coronary artery are accompanied with the expression of some BNPs, and can reduce the proliferation and migration of smooth muscle cells through binding to NPR-A.17 This study showed that NT-pro BNP levels in patients with AIS were positively correlated with IMT and NIHSS scores (P<0.05), indicating that the occurrence of atherosclerosis is also a risk factor for the increase of NT-pro BNP levels, and at the same time increases the risk of the incidence of ischemia stroke. The gene discussed is NPPB; the disease is atherosclerosis.