There are four types of surfactant proteins namely “surfactant protein– A (SP-A)”, “surfactant protein–B (SP-B)”, “surfactant protein–C (SP-C)” and “Surfactant protein– D (SP-D)”.6 Among them, the most abundant surfactant protein is “surfactant protein –A”.7 SP-A maintains the lungs innate immunity by protecting the lungs against allergens and bacteria.8 There is a dearth of lung specific biomarkers causing limitation in diagnosis of COPD and development of novel therapies. This evidence concerns the gene SFTPD and chronic obstructive pulmonary disease.