Numerous studies have explained an association between liver markers and diabetes.5Ohlson et al, 1988; reported in Swedish male that baseline ALT was a predictor of the incidence of type 2 diabetes after 13.5 years of follow-up in a cohort of 766 subjects with a significant fourfold increased risk for males in the upper quintile compared to the lowest quintile.13 However, in Pakistan previous study reported that elevated ALT levels are an independent significant risk factor for T2DM among women. The gene discussed is GPT; the disease is diabetes mellitus.