IL2 and infection: With regard to the functional aspect of IL-2-driven T cell responses, we showed that these cells after the intense proliferative responses (both in RAG−/− hosts and in lympho-depleted B6 hosts with LCMV infections) are able to fully differentiate into effector and memory cells that are functional for controlling pathogenic infections at levels equivalent to those of antigen-induced effector/memory cells (Figure 7).