A functional SNP in the promoter region of the GSK3beta gene (nt −171 to +29), which also shows a general association to impulsivity and suicide risk among patients with bipolar disease, was found to influence the age at onset of BD, as well as the response to treatment with antidepressant, lithium salts and chronotherapeutics (53–55). This evidence concerns the gene GSK3B and Behcet disease.