Gonzalez et al. performed a family-based association study of circadian genes and BD in a Latino population, reporting nominal associations between SNPs of CSNK1E, ARNTL, CSNK1D, CLOCK, as well as statistically significant associations between CSNK1E and ARNTL haplotypes and BD, with either increased susceptibility or protective effect against the development of the disorder respectively (36). This evidence concerns the gene CSNK1E and Behcet disease.