Shi et al. demonstrated the three-way interaction of BHLHE40, TMEM165 (transmembrane protein 165), and CSNK1E with bipolar disorder (37), while McGrath et al. focusing their analysis on the RORA and RORB genes, found that 4 RORB SNPs were associated with bipolar 1 disorder (38). This evidence concerns the gene TMEM165 and bipolar disorder.