Overall, 43 (20.1%) of the subjects received a diagnosis of comorbid current depression, and 51 (31.9%) had ongoing antidepressant treatment. Abnormal CRP levels in schizophrenia [>3 mg/L, N = 63 (28.8%)] were found to be associated with antidepressant consumption, but not with depression. In a multivariate model, abnormal CRP was associated with antidepressant consumption (aOR 2.8, 95%CI 1.22–6.62). Metabolic syndrome was also independently associated with abnormal CRP (aOR2.6, 95%CI 1.01–6.71). Here, CRP is linked to major depressive disorder.