HIF1A and neoplasm: Increased plasma and tumor vitamin C levelsDecreased tumor growth and decreased metastasisIncreased survivalGeneration of ROS (e.g., H2O2, ascorbyl radicals)Altered gene expression (e.g., VEGF, bFGF, MMP2, cell cycle progression genes)Altered protein levels (e.g., HIF-1α, GLUT-1)