CASP3 and colon carcinoma: However, so far it has not been reported for C. ragusina L. Compound 2 was shown to activate caspase-3 and caspase-9 in human colon carcinoma HCT-116 cells and decrease tumor volume and weight in immunodeficient mice that were inoculated with HCT-116 cells (Hu et al., 2012).