Death et al. (2003) discovered that hyperglycemia disturbed the regulation of MMP/TIMP and increased the activities of MMP-9, MMP-2 and MMP-1 in vascular cells, stimulating the degradation of the extracellular matrix and producing an imbalance in diabetes. Our results have clarified that an increase of MMP-2 and MMP-9 expression may be a factor resulting in impairment of WH, while topical treatment with adelmidrol + trans-traumatic acid prevented overexpression of both MMPs by favoring WH in diabetic mice 6 and 12 days after the injury. Here, MMP1 is linked to diabetes mellitus.