NGFR and cancer: In gastric cancer, p75NTR has been reported to inhibit the invasive and metastatic abilities of cancer cells in correlation with the downregulation of metalloprotease-9 (MMP9) proteins and upregulation of the tissue inhibitor of matrix metalloprotease-1 (TIMP1) protein by suppressing the NFkappaB signal transduction pathway (Jin et al., 2007).