Importantly, no individuals described in this and previous studies had visible plexiform neurofibromas (0/127 ≥9 years) or histopathologically confirmed cutaneous (0/59 ≥19 years) or subcutaneous neurofibromas (0/37 ≥19 years) (Table S6).4,25,26 Similar to the NF1 p.Arg1809 cohort, no symptomatic OPGs were observed in the studied group. This evidence concerns the gene NF1 and plexiform neurofibroma.