As such, the 2016 American Association for Cancer Research (AACR) Childhood Cancer Predisposition workshop recommends that children fulfilling one or more NIH diagnostic criteria have the NF1 diagnosis molecularly confirmed.43 Establishing a correct NF1 diagnosis, especially in young individuals who do not meet the clinical criteria, is crucial in determining appropriate clinical management. Here, NF1 is linked to childhood malignant neoplasm.