NF1 and pilocytic astrocytoma: We also provide proof of the existence of low-grade pilocytic astrocytomas with the NF1 p.Met992del pathogenic variant and loss of heterozygosity (LOH) at p.Met992del and three intragenic NF1 microsatellite markers in three lesions from a single NF1-affected individual, establishing these as NF1-associated tumors.