In the current study, none of the individuals showed symptomatic spinal neurofibromas (Table 1), although in the original report a single symptomatic spinal tumor was found;4 nevertheless, even combined that remains significantly less prevalent than in the cohort of individuals with the NF1 missense pathogenic variants at residues 844–848 (P < 0.0001, statistically significant after B–H correction at FDR 0.01). This evidence concerns the gene NF1 and Spinal neurofibroma.