Finally, individuals with p.Met992del had a significantly lower prevalence of cognitive impairment and/or learning disabilities compared with the cohorts of individuals with the NF1 missense pathogenic variants at codon 1809 and the general NF1 population (P = 0.0018 and P = 0.0082, both statistically significant after B–H correction at FDR 0.05; Table 2). This evidence concerns the gene NF1 and Cognitive impairment.