NF1 and Macrocephaly: In addition, macrocephaly was observed less frequently than in the cohorts of individuals with the NF1 missense pathogenic variants at residues 844–848 and “classic” NF1 clinical presentation (P = 0.0267 and P = 0.0111, respectively, not statistically significant after B–H correction at FDR 0.05; Table 2).