One of these cases (UAB-R6975), a 9-year-old girl with serious neurocognitive issues (severely deficient verbal intellectual function, impaired expressive and receptive language delays, and features of autism spectrum disorder, generalized anxiety disorder, and dyspraxia), was found to have a constitutional 15q13.3 duplication, encompassing the CHRNA7 (MIM 118511) and OTUD7A (MIM 612024) genes (Table S1). This evidence concerns the gene CHRNA7 and generalized anxiety disorder.