In the univariate analysis, variables associated with shorter survival were perioperative blood transfusion, lower hemoglobin concentration, higher INR value, older age, male, ASA class ≥3, comorbidities (diabetes, coronary arterial disease, etc), higher pretreatment CEA level, longer anaesthesia time, advanced cancer stage, specific pathologic findings (poor differentiation, mucinous histology, lymphovascular invasion, and perineural invasion), preoperative chemotherapy and/or radiotherapy, and postoperative chemotherapy or radiotherapy (Table 3). Here, CEACAM5 is linked to cancer.