(Supplementary Table S2) Multivariable analysis identified other prognostic determinants for overall survival (Table 4), including older age (HR = 1.03), male (HR = 1.25), ASA class ≥3 (HR = 1.62), heart failure (HR = 1.42), chronic kidney disease (HR = 1.48), higher pretreatment CEA (on base-10 logarithmic scale, HR = 1.57), cancer stage (III vs. I, HR = 2.19), pathologic lymphovascular invasion (HR = 1.41), perineural invasion (HR = 1.51), and preoperative chemotherapy and/or radiotherapy (HR = 2.18). This evidence concerns the gene CEACAM5 and heart failure.