(Supplementary Table S2) Other independent prognostic factors for disease-free survival included preoperative CEA level (on base-10 logarithmic scale, HR = 1.84), cancer stage (II vs. I, HR = 2.83; III vs. I, HR = 5.82), anaesthesia time (on base-2 logarithmic scale, HR = 1.28), pathologic lymphovascular invasion (HR = 1.37) and perineural invasion (HR = 1.73), signet-ring histology (HR = 1.6), preoperative chemotherapy and/or radiotherapy (HR = 2.19), and postoperative radiotherapy (HR = 2.22) (Table 4). Here, CEACAM5 is linked to cancer.