In a rat model of radiation-induced lung injury, protein expression of integrin αvβ6, TGF-β1, TβRII, Smad3, and p-Smad2/3 was undetectable in the normal alveolar epithelium but increased in association with lung fibrosis six months after radiation exposure51. The gene discussed is TGFBR2; the disease is pulmonary fibrosis.