BIRC5 and breast cancer: In Hippo signaling (hsa04390, P(non-)T-to-C = 3.5 × 10−7, one-sided Fisher’s exact test, Benjamini–Hochberg adjustment, n(non-)T-to-C = 34), among targets derived only from non-T-to-C peaks (Supplementary Fig. 5), miRNA regulation on BIRC5 (Survivin) was notable, since this terminal pathway node is upregulated in breast cancer cells, while its silencing inhibits metastasis and induces apoptosis27.