Examination of 4 differentiation-related genes (AR, NR3C1, KLK3, FKBP5) and 6 CSC genes (ALDH7A1, BCL-2, CDH2, ITGA2, MYC, and STAT3) in RNA-Seq (Supplementary Fig. 17b-d), for which we have assessed their protein levels during LAPC9 AD to CRPC transition (Fig. 2a; Supplementary Fig. 16a), reveals that, consistent with western blotting, AR and FKBP5 are much reduced and KLK3 is undetectable whereas NR3C1 is slightly increased in LAPC9 CRPC (Supplementary Fig. 17c). Here, KLK3 is linked to Alzheimer disease.