PCa metastases, which are generally clonal in origin, may manifest as either AR+ or AR−/lo, as evidenced by commonly used, mostly metastasis-derived PCa cell lines (e.g., PC3, DU145, and PPC-1 being AR- whereas LNCaP, LAPC9, VCaP, LAPC4 being AR+), as well as by recent positron emission tomography/computed tomography-based AR-axis imaging analysis32,33. The gene discussed is AR; the disease is posterior cortical atrophy.