AR and neoplasm: Comparing the intrinsic biological properties, as well as tumor-regenerating potential in AR+ and AR-KO cells in different androgen environments, we find that AR+ LNCaP clones display higher clonal and sphere-forming potential in DHT-containing media compared to AR-KO clones (Supplementary Fig. 7a, b), which is associated with higher proliferation in AR+ cells (Supplementary Fig. 7c).