AR and Alzheimer disease: Interestingly, when these 4 models transition from androgen-dependent (AD, i.e., androgen-sensitive) to a castration-resistant (CR; androgen-independent or AI) state during serial propagation in castrated mice (Fig. 1d; Methods), CR tumors display the same 3 AR immunostaining patterns observed in the clinical CRPC specimens (Fig. 1e; Supplementary Fig. 2).