BCL-2 overexpression in LNCaP cells (Supplementary Fig. 15f) enhances CSC-enriched holoclone11,14–17 formation in regular (Supplementary Fig. 15g) and Enza-containing (Fig. 7g) media and also promotes tumor growth in intact (Fig. 7h; Supplementary Fig. 15h, i) and castrated (Supplementary Fig. 15j) mice. Here, BCL2 is linked to neoplasm.