AR and posterior cortical atrophy: Our studies suggest that AR+ and AR−/lo PCa cell subpopulations, which co-exist in untreated primary tumors2–14, may co-evolve under pressure from castration/Enza to generate AR+/hi (LNCaP-type), as well as AR−/lo (LAPC9-type) CRPC cells/clones (Fig. 8k).