The master regulator of cellular apoptosis p53 (TP53) or its key cofactors are almost universally inactivated in human malignancies11—while multiple copies of TP53 protect elephants from a high rate of cancer proportionate to their high cellular mass12, TP53 mutations can be viewed as “the elephant in the room” of all cancer therapy, since most treatments intend to activate this master regulator which ironically is absent from most cancers. This evidence concerns the gene TP53 and cancer.