In patients with type 2 diabetes mellitus, OGIS was 14% lower and beta cell function assessed from ΔAUC(C-peptide)0–180 min/ΔAUC(glucose)0–180 min as well as from ΔAUC(insulin)0–180 min/ΔAUC(glucose)0–180 min was 71% and 78% lower than CON, respectively. The gene discussed is INS; the disease is diabetes mellitus.