They have further demonstrated that MMSET upregulates MAF transcription through activation of mitogen-activated protein kinase (MAPK) pathway, and that ectopic expression of MAF rescues t(4;14) MM cells from toxicity of MMSET depletion or MEK (MAPK kinase) inhibition, identifying MAF oncogene as a downstream effector of MMSET37. This evidence concerns the gene NSD2 and Miyoshi myopathy.