We identified significant underrepresentation of genes hyper-methylated in AML (P = 0.006; normalized enrichment score (NES) = −1.49; Supplementary Figure 4A) and genes related to apoptosis (P = 0.042; NES = −1.33) in the ZF1-mutated patients compared to GATA2 wild-type patients. The gene discussed is GATA2; the disease is acute myeloid leukemia.