As H19 is strongly conserved32 and human H19 (hH19) is expressed in mature adipocytes compared to non-parenchymal cells in fat (Supplementary Data 4), we next asked if hH19 could be affected by obesity also in humans and quantified hH19 levels in scWAT and vWAT biopsies from 169 lean and obese patients. This evidence concerns the gene DUSP6 and obesity due to melanocortin 4 receptor deficiency.