Because of the role of PEGs in WAT-relevant processes like white adipogenesis and adipocyte cell size regulation, it is plausible to assume that H19 preserves BAT homeostasis during DIO by its cell-intrinsic control of mitochondrial biogenesis in mature brown adipocytes and by maintaining quiescence of obesity-predisposing PEGs in BAT. The gene discussed is H19; the disease is obesity due to melanocortin 4 receptor deficiency.