Alterations in BAT thermogenesis were confirmed by elevated and decreased Uncoupling Protein 1 (Ucp1) and ELOVL Fatty Acid Elongase 3 (Elovl3) mRNA expression during cold or diet-induced obesity (DIO), respectively (Fig. 1e, f). The gene discussed is ELOVL3; the disease is obesity due to melanocortin 4 receptor deficiency.