Alterations in BAT thermogenesis were confirmed by elevated and decreased Uncoupling Protein 1 (Ucp1) and ELOVL Fatty Acid Elongase 3 (Elovl3) mRNA expression during cold or diet-induced obesity (DIO), respectively (Fig. 1e, f). Here, UCP1 is linked to obesity due to melanocortin 4 receptor deficiency.