To exclude the possibility that apoA-IV in vivo inhibition was due to anti-oxidant activity42 as opposed to blockade of platelet αIIbβ3 integrins, we used a cremaster arteriole intravital microscopy thrombosis model which does not involve oxidative stress as it induces mild vascular injury with a laser43,44. This evidence concerns the gene APOA4 and Venous thrombosis.