In the early stage of EMT, the adhesion molecules (such as E-cadherin and β-catenin) are downregulated and the N-cadherin and vimentin protein levels are upregulated; thus, tumor cells lose their epithelial features and acquire a mesenchymal phenotype, which leads to invasive and migratory behaviors[27–32]. The gene discussed is CDH1; the disease is neoplasm.