Before treatment, both groups showed a similar CXCR4+ CCF in tumor tissue (Fig 4A and B); however, after T22‐GFP‐H6‐FdU treatment, the CXCR4+ CCF was reduced at 24 h and reached its valley at 48 h (Fig 4A and B). Here, CXCR4 is linked to neoplasm.