The previous demonstration of MIC capacity for CXCR4‐overexpressing (CXCR4+) CRC cells (Croker & Allan, 2008; Zhang et al, 2012), and its inhibition by CXCR4 downregulation (Murakami et al, 2013; Wang et al, 2014), identifies these cells as MetSCs (Oskarsson et al, 2014). Here, CXCR4 is linked to colorectal carcinoma.