Moreover, CXCR4‐overexpressing (CXCR4+) cells have metastasis‐initiating capacity (MICs) in CRC (Croker & Allan, 2008; Zhang et al, 2012), whereas CXCR4 RNAi‐mediated downregulation or blockade of membrane localization inhibits hepatic and lung metastases (Murakami et al, 2013; Wang et al, 2014). Here, CXCR4 is linked to colorectal carcinoma.