CXCR4 and colorectal carcinoma: Based on our previous findings of high T22‐GFP‐H6 nanoparticle internalization in high CXCR4‐expressing PTN Mets and low internalization in low CXCR4‐expressing LN Mets in CRC mouse models (Céspedes et al, 2016), our results suggest that the high T22‐GFP‐H6‐FdU antimetastatic effect observed in peritoneal metastases may come from its high internalization in these foci, leading to high intracellular FdU concentration and DNA damage above DNA repair capacity, triggering in turn high cell killing and a reduction in foci number as well as in CXCR4+ CCF at the end of treatment.