For example, for mammalian ESCRT-I, there are single genes for the VPS23 [also called TSG101 (tumour susceptibility gene 101)] and VPS28 subunits, but four variants of VPS37 (VPS37A–D) and three variants of MVB12 (MVB12A/B and UBAP1) [17]. The gene discussed is UBAP1; the disease is neoplasm.