ATXN3 and amyotrophic lateral sclerosis: Here we focused on exploring the potential to study neurodegenerative diseases by applying and optimizing the technique using transgenic zebrafish expressing mutated forms of the proteins fused in sarcoma (FUS) and ataxin-3 to model amyotrophic lateral sclerosis (ALS) and spinocerebellar ataxia type-3 (SCA3), respectively.