GNRH1 and pachyonychia congenita: For example, a 1996 randomized, double-blind, multicenter study compared 50 mg once-daily bicalutamide plus LHRH with 250 mg (3 times a day) flutamide plus LHRH in patients with untreated metastatic PC and reported that bicalutamide was better tolerated than flutamide, although efficacy was similar [33].