In the same way, Hanrahan et al. [28] found a significant increase of VEGFR-1 mRNAs in T3/T4 colorectal carcinomas compared to lymphogenously metastasising tumors, and Lebok et al. [29] showed that low VEGFR-1 tumor expression was associated with lower survival and correlated with an advanced disease status in breast cancer. This evidence concerns the gene FLT1 and breast carcinoma.