NR3C2 and fibrosis: Intriguingly, Ji et al. demonstrated that mineralocorticoid receptor (MR) antagonism by liposome-encapsulated spironolactone (Lipo-SP) could alleviate bleomycin-induced acute pulmonary injury and fibrosis, partially by reducing circulating inflammatory Ly6Chigh monocyte expansion and repressing alternatively activated mononuclear phagocytes in the alveolar compartment [123, 124].