SNAI2 and breast cancer: In a previous in vitro study, regardless of the significantly higher expression levels of both SNAI2 and ZEB2 genes in metastatic BC cell lines, only moderate DNA methylation differences were found in SNAI2 between highly and poorly metastatic lines, which was in contrast to the ZEB2 gene, which was markedly hypomethylated in highly metastatic cell lines [41].