PNPLA3 and myeloid sarcoma: The present study, aiming to evaluate the role of PNPLA3 rs738409 variant in the development of HS and MS in a large series of patients with CD after starting GFD, demonstrated that G and GG alleles were independent predictive factors for HS development (OR 1.97; p < 0.01 for G carriers and OR 6.9; p < 0.001 for GG carriers).